GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4936613 | 1 | rs4936613 | chr11:121204601 | SC5DL | chr11:121163388-121184117:+ | -0.33 | -4.25 | 2.72E-5 | Response to taxane treatment (placlitaxel) |
| BLCA | cis | rs951366 | 1 | rs4951261 | chr1:205717823 | PM20D1 | chr1:205797154-205819245:- | 0.22 | 4.21 | 3.16E-5 | Menarche (age at onset) |
| BLCA | cis | rs951366 | 1 | rs4951261 | chr1:205717823 | RAB7L1 | chr1:205737115-205744610:- | -0.35 | -5.98 | 5.12E-9 | Menarche (age at onset) |
| BLCA | cis | rs10935120 | 1 | rs4955485 | chr3:134295843 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.51 | 4.32E-13 | Height |
| BLCA | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.81 | 5.66E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs4955555 | chr3:134286427 | CEP63 | chr3:134204575-134293852:+ | 0.22 | 3.83 | 0.00015 | Height |
| BLCA | cis | rs7714584 | 1 | rs4958424 | chr5:150225036 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.33 | 1.71E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs4958426 | chr5:150278346 | LOC134466 | chr5:150310000-150326146:- | 0.56 | 6.99 | 1.21E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs4958843 | chr5:150224924 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.33 | 1.71E-7 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs4958848 | chr5:150271122 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 5.81 | 1.33E-8 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs4958852 | chr5:150330631 | LOC134466 | chr5:150310000-150326146:- | 0.63 | 6.7 | 7.39E-11 | Crohn's disease |
| BLCA | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | ADAL | chr15:43622872-43646094:+ | -0.39 | -4.79 | 2.4E-6 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs496584 | chr15:43831923 | CATSPER2 | chr15:43922774-43959900:- | -0.29 | -4.43 | 1.25E-5 | Tumor biomarkers |
| BLCA | cis | rs9815354 | 1 | rs4973991 | chr3:41927273 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.83 | 1.72E-20 | Diastolic blood pressure |
| BLCA | cis | rs10935120 | 1 | rs4974483 | chr3:134219001 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.5 | 4.62E-13 | Height |